You can start Botox as early as 18 years old but you probably don’t need to. For some people, this may mean starting Botox treatment as soon as your early 20s, if you’re prone to wrinkles and want to prevent them from occurring. There is no upper age limit for people who want to have Botox. In fact, many women enjoy the refreshed look they can get from Botox and complementary treatments when they are in their 60s or older.